Synthesis and bacteriostatic activity of benzimidazole compounds

HUANG Tao,CHENG Kanghua,GU Xiaoli

Journal of Nanjing Forestry University (Natural Sciences Edition) ›› 2013, Vol. 37 ›› Issue (02) : 151-155.

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Journal of Nanjing Forestry University (Natural Sciences Edition) ›› 2013, Vol. 37 ›› Issue (02) : 151-155. DOI: 10.3969/j.issn.1000-2006.2013.02.027

Synthesis and bacteriostatic activity of benzimidazole compounds

  • HUANG Tao,CHENG Kanghua*,GU Xiaoli
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Abstract

To find new organic wood preservative with broad-spectrum and hyperactivity, seven 5-substituted benzimidazole compounds were synthesized from 4-substituted ο-phenylenediamine through multi-step reactions including acylation, cyclization and so on. Their chemical structures were confirmed by melting points, MS, 1H NMR and elemental analysis. The target compounds were screened for antimicrobial activity by agar-well diffusion method against white-rot fungi(Coriolus versicolor), brown-rot fungi(Gloeophyllum trabeum)and moulds(Aspergillus niger and Trichoderma viride). The preliminary fungicidal tests showed that seven compounds had no fungicidal activities, but some of them had anti-mould activities. Compound 4a at concentration of 1.0% showed strong anti-mould activity which was significantly higher than that of pentachlorophenate, and compounds 4b was equal to contrast.

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HUANG Tao,CHENG Kanghua,GU Xiaoli. Synthesis and bacteriostatic activity of benzimidazole compounds[J]. Journal of Nanjing Forestry University (Natural Sciences Edition). 2013, 37(02): 151-155 https://doi.org/10.3969/j.issn.1000-2006.2013.02.027

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