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同源四倍体自然群体的连锁不平衡分析模型(PDF)

《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

Issue:
2014年04期
Page:
29-33
Column:
研究论文
publishdate:
2014-07-01

Article Info:/Info

Title:
A model for linkage disequilibrium analysis in an autotetraploid natural population
Article ID:
1000-2006(2014)04-0029-05
Author(s):
FENG Sisi1 WANG Jianxin12 PANG Xiaoming1 WU Rongling1*
1.Center for Computational Biology, Beijing Forestry University, Beijing 100083,China;
2. School of Information Science &
Technology, Beijing Forestry University,Beijing 100083,China
Keywords:
autotetraploid linkage disequilibrium statistical model expectation-maximization algorithm
Classification number :
S722
DOI:
10.3969/j.issn.1000-2006.2014.04.006
Document Code:
A
Abstract:
More than 50% of angiosperms are polyploidy, or have experienced genome doubling in their evolutionary history. Thus, polyploids provide a valuable tool to study the genetics and evolution of plants. Linkage disequilibrium analysis has been widely used to infer the genetic structure, differentiation and diversity of natural populations, but its basic principle was found on a diploid population. In this article, we have derived a model for linkage disequilibrium analysis between a pair of molecular markers for the first time based on meiotic properties of autotetraploids. Computer simulation has been performed to examine the usefulness of the new model and determine the condition of its utilization.

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Last Update: 2014-07-31