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转基因植物中外源基因的沉默(PDF)

《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

Issue:
2000年03期
Page:
56-60
Column:
研究论文
publishdate:
1900-01-01

Article Info:/Info

Title:
The Silencing of Transgenes in Transgenic Plants
Article ID:
1000-2006(2000)03-0056-05
Author(s):
Rao Hongyu\ Huang Minren\ Wang Mingxiu
Key Laboraory of Forest Genetics & Gene Engineering Nanjing Forestry University\ Nanjing\ 210037
Keywords:
Transgenic plants Transgene silencing Methylation Gene copy number Cosuppression
Classification number :
Q78;Q812
DOI:
10.3969/j.jssn.1000-2006.2000.03.018
Document Code:
A
Abstract:
Analysis of the large collection of genetically modified plants has shown that transgenes in a great of transgenic plants can’t be expressed as expected. In some cases, transgenes are inactive and the transgene expression couldnt be detected throughly, which are called as gene silencing. Transgene silencing has greatly hinderred the application of the technic of plant gene transformation. Various factors seem to play a role, including of DNA methylation, transgene copy number and the DNA region where transgenes inserted. Basically there are two kinds of gene silencing, transcriptional gene silencing (TGS) and post transcriptional gene silencing (PTGS). According to the study on a mount of transgenic plants, several possible mechanisms by which silencing is achieved have been presented, such as RdRP cRNA , RNA threshold and RdDM models. The more understandings to the mechanisms will largely speed the research on plant gene engineering.

References

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Last Update: 1900-01-01