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|Table of Contents|

位点特异性DNA内切酶在植物基因打靶中的应用(PDF)

《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

Issue:
2012年06期
Page:
130-134
Column:
综合述评
publishdate:
2012-12-05

Article Info:/Info

Title:
The application of sitespecific DNA endonucleases in plant gene targeting
Author(s):
CHENG Qiang XU Meng HUANG Minren*
Jiangsu Key Laboratory for Poplar Germplasm Enhancement and Variety Improvement,  Nanjing Forestry University, Nanjing 210037, China
Keywords:
plant gene targeting zinc finger nuclease TAL effector nuclease
Classification number :
Q948
DOI:
10.3969/j.jssn.1000-2006.2012.06.026
Document Code:
A
Abstract:
Gene targeting is a powerful tool for sitespecific insertion, deletion and replacement of DNA in genome. Gene targeting technology in plants is far from routine due to the low frequency of homologous recombination that limits the study of gene function and molecular breeding. Recently, breakthrough has been made in the engineered DNA binding domains combined with zinc finger protein and transcription activatorlike effector. Engineered DNA binding domain fusing endonucleases can specifically breaks the DNA doublestrand, then generate sitedirected mutagenesis and facilitate homologous recombination. In this review, we focus on the application of zinc finger nuclease and TAL effector nuclease in sitedirected mutagenesis and gene targeting of plant genome and analyze their existing problems.

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Last Update: 2012-11-30