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新型水溶性C60脱氢枞胺吡咯烷衍生物的合成及抗HIV活性(PDF)

《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

Issue:
2013年02期
Page:
147-150
Column:
研究论文
publishdate:
2013-03-31

Article Info:/Info

Title:
Synthesis and anti-HIV activity of a novel water-soluble C60-dehydroabietylamine pyrrolidine derivative
Author(s):
HU JunqiangLIN Zhongxiang*
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Keywords:
C60 dehydroabietylamine water-soluble anti-HIV activity
Classification number :
TQ463.5
DOI:
10.3969/j.issn.1000-2006.2013.02.026
Document Code:
A
Abstract:
A novel water-soluble dehydroabietylamine fullerenol was synthesized and its anti-HIV activity had been evaluated. It was prepared by the hydroxylation of fulleropyrrolidine which was synthesized through the 1,3-dipolar cycloaddition of C60, sarcosine and glyoxal dehydroabietylamine single Schiff base. The structures of all the compounds were characterized by IR, ESI-MS, MALDI-TOF-MS, 1H NMR, 13C NMR, elemental analysis and TGA. The bioassay results showed that the synthesized dehydroabietylamine fullerend had great anti-HIV activity against HIV-1 reverse transcriptase in vitro and IC50 was 47.89 μg/mL.

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Last Update: 2013-03-31