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|Table of Contents|

苯并咪唑类化合物的合成及其抑菌活性(PDF)

《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

Issue:
2013年02期
Page:
151-155
Column:
研究论文
publishdate:
2013-03-31

Article Info:/Info

Title:
Synthesis and bacteriostatic activity of benzimidazole compounds
Author(s):
HUANG TaoCHENG Kanghua*GU Xiaoli
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Keywords:
benzimidazole wood preservation antibacterial activity
Classification number :
O626
DOI:
10.3969/j.issn.1000-2006.2013.02.027
Document Code:
A
Abstract:
To find new organic wood preservative with broad-spectrum and hyperactivity, seven 5-substituted benzimidazole compounds were synthesized from 4-substituted ο-phenylenediamine through multi-step reactions including acylation, cyclization and so on. Their chemical structures were confirmed by melting points, MS, 1H NMR and elemental analysis. The target compounds were screened for antimicrobial activity by agar-well diffusion method against white-rot fungi(Coriolus versicolor), brown-rot fungi(Gloeophyllum trabeum)and moulds(Aspergillus niger and Trichoderma viride). The preliminary fungicidal tests showed that seven compounds had no fungicidal activities, but some of them had anti-mould activities. Compound 4a at concentration of 1.0% showed strong anti-mould activity which was significantly higher than that of pentachlorophenate, and compounds 4b was equal to contrast.

References

[1] Thompson R. The chemistry of wood preservation[M]. Cambridge: The Royal Society of Chemistry Press,1991.
[2] 曹金珍.国外木材防腐技术和研究现状[J].林业科学,2006,42(7):120-126. CAO J Z. A review on wood preservation technologies and research[J]. Scientia Silvae Sinicae, 2006, 42(7):120-126..
[3] 姜卸宏,曹金珍.季铵盐类化合物(QAC)在木材防腐中的应用[J].林产工业,2007,34(2):3-8. Jiang X H, Cao J Z. Review on application of quaternary ammonium compounds(QAC)in wood preservation[J].China Forest Products Industry, 2007, 34(2):3-8.
[4] 程康华,朱昆,翟炜.一种水载型有机木材防腐剂的制备及其性能研究[J].林产化学与工业,2011,31(2):76-81. Cheng K H, Zhu K, Zhai W. Preparation and performance study of a waterborne organic wood preservative[J]. Chemistry and Industry of Forest Products, 2011,31(2):76-81.
[5] 宋琳,谢毓元,王惠贞.苯并咪唑Schiff碱的合成及其杀菌活性[J].中国药物化学杂志,2000,10(2):92-94. Song L, Xie Y Y, Wang H Z. Synthesis and antibacterial activity of benzimidazole schiff base[J]. Chinese Journal of Medicinal Chemistry, 2000,10(2):92-94.
[6] 朱莉,廖展如,龙云飞,等.含苯并咪唑锌配合物的合成、表征及晶体结构[J].无机化学学报,2004,20(4):399-402. Zhu L, Liao Z R, Long Y F, et al. Syntheses and crystal structures of znic(Ⅱ)complex containing benzimidazolyl[J]. Chinese Journal of Inorganic Chemistry, 2004, 20(4):399-402.
[7] 田敏,王陆瑶,陈邦,等.芳香基苯并咪唑衍生物的合成、表征及抑菌活性研究[J].化学通报,2005,68(9):709-713. Tian M, Wang L Y, Chen B, et al. Synthesis,structure and antimicrobial activity of aromatic benzimidazole derivatives[J]. Chemistry, 2005, 68(9):709-713.
[8] 李莹莹,周永花,郭玉芳,等.苯并咪唑衍生物的合成改进[J].有机化学,2006,26(8):1097-1099. Li Y Y, Zhou Y H, Guo Y F, et al. Improvement of the synthesis of benzimidazole derivatives[J]. Chinese Journal of Organic Chemistry, 2006, 26(8):1097-1099.
[9] Zhang S H, Zhan T R, Cheng K, et al. Simple and efficient of novel glyeosyl thiourea derivatives as potential antitumor agents[J]. Eur J Med Chem, 2008,43:2778-2783.
[10] Hwu J R, Singha R, Hong S C, et al. Synthesis of new benzimidazole-coumarin conjugates as anti-hepatitis C virus agents[J]. Antiviral Res, 2008,77:157-162.
[11] Kazuya K, Hannak R B, Guo M J, et al. Toward bifunctional antibody catalysis[J]. Bioorg Med Chem, 2006,14:6189-6196.
[12] Kwon C H, Nagasawa H T, DeMaster E G, et al. Acyl N-protected α-aminoacyl, and peptidyl derivatives as prodrug forms of the alcohol ddeterrent agent cyanamide[J].J Med Chem, 1986,29:1922-1929.
[13] 康汝洪,马志博,刘俊玲.相转移催化合成S-甲基异硫脲盐[J].化学试剂,1994,16(6):373,380. Kang R H, Ma Z B, Liu J L. Phase transfer catalyzed synthesis of S-methylisothiourea salts[J]. Chemical Reagents, 1994, 16(6):373,380.
[14] Siya R, Dean S W, Linda L W, et al. Synthesis and biological activity of certain alkyl 5-(alkoxycarbonyl)-1H-benzimidazole-2-carbarnates and related derivatives[J]. J Med Chem, 1992,35(3):539-547.
[15] 中华人民共和国卫生部,消毒技术规范[S].北京:中华人民共和国卫生部,2002.

Last Update: 2013-03-31