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毛杨梅树皮原花色素对小鼠急性毒性及抗氧化性的影响(PDF)

《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

Issue:
2013年04期
Page:
85-89
Column:
研究论文
publishdate:
2013-07-15

Article Info:/Info

Title:
Acute toxicity of proanthocyanidins from Myrica esculenta Buch. Ham. bark on mice and its antioxidative properties
Article ID:
1000-2006(2013)04-0085-05
Author(s):
ZHANG Lun LIU Gongjun HE Baiqiu WANG Fei
Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University,Nanjing 210037, China
Keywords:
Myrica esculenta Buch. Ham. bark proanthocyanidins acute toxicity antioxidative properties
Classification number :
S718.4; TQ91
DOI:
10.3969/j.issn.1000-2006.2013.04.016
Document Code:
A
Abstract:
The security of proanthocyanidins extractive from Myrica esculenta Buch. Ham. was investigated by analyzing its acute toxicity and antioxidative properties in vivo to mice. The results showed that the LD50 of proanthocyanidins extractive from M. esculenta Buch. Ham. bark in mice was 5 g/kg, and the activities of catalase(CAT), superoxide dismutase(SOD)significant increased(p<0.05); the contents of malondialdehyde(MDA)decreased in mice serum. In liver, the activities of CAT increased(p<0.05), the content of MDA increased but was not significant difference with control(p>0.05). Thus, during the acute oral toxicity, the extractive from M. esculenta Buch. Ham. bark did not reveal any toxic effects in ICR mice(data not shown)and have some antioxidative properties in vivo.

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Last Update: 2013-07-30