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PLGA基载药复合微球的制备及其释放性能(PDF)

《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

Issue:
2016年02期
Page:
95-99
Column:
研究论文
publishdate:
2016-03-30

Article Info:/Info

Title:
Preparation and drug release properties of PLGA complex microparticles
Article ID:
1000-2006(2016)02-0095-05
Author(s):
WANG Fang YUAN Jian LIU Xiuxiu FANG Bing YANG Siqian GAO Qinwei
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Keywords:
poly(lactide-co-glycolicacid)(PLGA) bovine serum albumin(BSA) chitosan microparticle drug release
Classification number :
TQ463
DOI:
10.3969/j.issn.1000-2006.2016.02.016
Document Code:
A
Abstract:
Poly(lactic-co-glycolic acid)(PLGA)microparticles were prepared by an emulsion-solvent evaporation technique using bovine serum albumin(BSA)as model drug. When the ratio of shell to core was 1:1, ratio of water to oil 3:5, dispersant concentration 0.5%, and the ultrasonic emulsification time 2 min, PLGA microparticles were 268.7 nm in diameter, characterized by the laser light scattering technique, and the drug content and drug encapsulation efficiency in this case were 30.88% and 46.95%, respectively. Scanning electron microscopy(SEM)and transmission electron microscope(TEM)showed the products were spherical in shape and uniform in dimension. When the PLGA microparticles surface was modified with chitosan(CS)by adsorption technique, the microparticle became larger in diameter. The presence of N element and the positive zeta potential of modified microparticles revealed the presence of CS on the surface of the PLGA microparticles. In vitro drug release test showed that the burst release of modified microparticles eased and the release time was prolonged compared with unmodified PLGA microparticles.

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Last Update: 2016-04-01