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阿维菌素/乙基纤维素载药纤维的制备及稳定性分析(PDF)

《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

Issue:
2018年06期
Page:
186-190
Column:
研究论文
publishdate:
2018-12-15

Article Info:/Info

Title:
Preparation and stability of avermectin-loaded ethylcellulose
Author(s):
ZENG Jianyong1 YU Yingying1 ZHANG Fangming1 LI Dabo2 ZHANG Guocai1*
(1. School of Forestry, Northeast Forestry University, Harbin 150040, China; 2. Honghuaerji Forestry Bureau of Inner Mongolia, Hulunbeir 021112, China)
Keywords:
avermectin(AVM) ethylcellulose(EC) drug-loaded fiber photostability thermostability agricultural and forest pest control
Classification number :
TQ450.6; S763
DOI:
10.3969/j.issn.1000-2006.201711016
Document Code:
A
Abstract:
【Objective】The photolysis of avermectin(AVM)always reduces the effectiveness of its application in agricultural and forest pest control. Here, a simple and economical method was used to improve its photostability.【Method】Ethylcellulose(EC)was employed as the carrier, while methanol was employed as the solvent for this process. AVM and EC were mixed in mass ratios(mAVM:mEC)of 1:10, 1:8, 1:6, 1:4, and 1:2 to prepare a series of solutions. Five times the volume of distilled water was then added to the solutions to precipitate the AVM-loaded EC(AVM/EC). The yield, drug-loading rate, photostability, and thermostability of AVM/EC, as well as the utilization rate of AVM, were then determined. Additionally, X-ray diffraction(XRD)analysis was performed to characterize the AVM/EC samples.【Result】The method achieved a shapeless and uniform dispersal of AVM in EC. When the mAVM:mEC was increased from 1:10 to 1:6, the AVM/EC yield exceeded 91.85%, while the AVM utilization rate was higher than 81.18%. Additionally, a photodegradation rate of under 15.80% was observed after ultraviolet light exposure for 12 h, and an AVM degradation less than 10.86% was observed. These results were obtained after the AVM/EC was kept at(54 ± 2)℃ for 14 days.【Conclusion】The solvent blending-water addition precipitation method yielded a homogeneous structure of AVM/EC that improved the photostability and thermostability of AVM. Therefore, this method could be a potential approach for the preparation of AVM for incorporation into dosage forms.

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Last Update: 2018-11-30