[1]张 伦,刘功骏,何柏球,等.毛杨梅树皮原花色素对小鼠急性毒性及抗氧化性的影响[J].南京林业大学学报(自然科学版),2013,37(04):085-89.[doi:10.3969/j.issn.1000-2006.2013.04.016]
 ZHANG Lun,LIU Gongjun,HE Baiqiu,et al.Acute toxicity of proanthocyanidins from Myrica esculenta Buch. Ham. bark on mice and its antioxidative properties[J].Journal of Nanjing Forestry University(Natural Science Edition),2013,37(04):085-89.[doi:10.3969/j.issn.1000-2006.2013.04.016]
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毛杨梅树皮原花色素对小鼠急性毒性及抗氧化性的影响
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《南京林业大学学报(自然科学版)》[ISSN:1000-2006/CN:32-1161/S]

卷:
37
期数:
2013年04期
页码:
085-89
栏目:
研究论文
出版日期:
2013-07-15

文章信息/Info

Title:
Acute toxicity of proanthocyanidins from Myrica esculenta Buch. Ham. bark on mice and its antioxidative properties
文章编号:
1000-2006(2013)04-0085-05
作者:
张 伦刘功骏何柏球王 飞
南京林业大学化学工程学院,江苏省生物质绿色燃料与化学品重点实验室,江苏 南京 210037
Author(s):
ZHANG Lun LIU Gongjun HE Baiqiu WANG Fei
Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University,Nanjing 210037, China
关键词:
毛杨梅树皮 原花色素 急性毒性 抗氧化性
Keywords:
Myrica esculenta Buch. Ham. bark proanthocyanidins acute toxicity antioxidative properties
分类号:
S718.4; TQ91
DOI:
10.3969/j.issn.1000-2006.2013.04.016
文献标志码:
A
摘要:
探讨了毛杨梅树皮原花色素提取物的安全性,分析了毛杨梅树皮原花色素对小鼠的急性毒性以及在小鼠体内的抗氧化性能。结果表明:毛杨梅树皮原花色素提取物经口的LD50为5 g/kg。毛杨梅树皮原花色素给药后,小鼠血清内的过氧化氢酶(CAT)、超氧化物歧化酶(SOD)活性显著性增加(p<0.05),丙二醛(MDA)含量减少。小鼠肝内的CAT活力显著增加,MDA含量也有所增加,但是并没有显著性差异(p>0.05)。因此,毛杨梅树皮原花色素属于实际无毒物质,毛杨梅树皮原花色素提取物对小鼠机体具有一定的抗氧化作用。
Abstract:
The security of proanthocyanidins extractive from Myrica esculenta Buch. Ham. was investigated by analyzing its acute toxicity and antioxidative properties in vivo to mice. The results showed that the LD50 of proanthocyanidins extractive from M. esculenta Buch. Ham. bark in mice was 5 g/kg, and the activities of catalase(CAT), superoxide dismutase(SOD)significant increased(p<0.05); the contents of malondialdehyde(MDA)decreased in mice serum. In liver, the activities of CAT increased(p<0.05), the content of MDA increased but was not significant difference with control(p>0.05). Thus, during the acute oral toxicity, the extractive from M. esculenta Buch. Ham. bark did not reveal any toxic effects in ICR mice(data not shown)and have some antioxidative properties in vivo.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-06-04 修回日期:2012-11-05
基金项目:国家林业公益性行业科研专项项目(201104019); 江苏高校优势学科建设工程项目(PAPD)
第一作者:张伦,博士生。*通信作者:王飞,教授,博士。E-mail: hgwf@njfu.edu.cn。
引文格式:张伦,刘功骏,何柏球,等. 毛杨梅树皮原花色素对小鼠急性毒性及抗氧化性的影响[J]. 南京林业大学学报:自然科学版,2013,37(4):85-89.
更新日期/Last Update: 2013-07-30