为探索具有高活性的有机木材防腐剂,以4-取代邻苯二胺为原料,经酰化、环合等步骤合成了7种5-取代苯并咪唑类衍生物,并经熔点、MS、1H-NMR及元素分析确证其结构。用滤纸片法研究目标化合物对白腐菌(彩绒革盖菌(Coriolus versicolor))、褐腐菌(密粘褶菌(Gloeophyllum trabeum))、霉菌(黑曲霉(Aspergillus niger)和绿色木霉(Trichoderma viride))的抑制活性,结果表明:合成的7种化合物对木材中的腐朽菌均没有抑菌活性,但部分化合物对木材腐朽菌中的霉菌有明显的抑制效果; 化合物4a在质量分数为1.0%时对两种霉菌就表现出较强的抑菌效果,且其效果明显优于对照试剂(五氯酚钠),化合物4b的抑菌效果则与对照试剂相当。
Abstract
To find new organic wood preservative with broad-spectrum and hyperactivity, seven 5-substituted benzimidazole compounds were synthesized from 4-substituted ο-phenylenediamine through multi-step reactions including acylation, cyclization and so on. Their chemical structures were confirmed by melting points, MS, 1H NMR and elemental analysis. The target compounds were screened for antimicrobial activity by agar-well diffusion method against white-rot fungi(Coriolus versicolor), brown-rot fungi(Gloeophyllum trabeum)and moulds(Aspergillus niger and Trichoderma viride). The preliminary fungicidal tests showed that seven compounds had no fungicidal activities, but some of them had anti-mould activities. Compound 4a at concentration of 1.0% showed strong anti-mould activity which was significantly higher than that of pentachlorophenate, and compounds 4b was equal to contrast.
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基金
收稿日期:2012-02-19 修回日期:2012-10-10
基金项目:国家林业公益性行业科研专项项目(201104032)
第一作者:黄涛,硕士生。*通信作者:程康华,教授。E-mail: chengkh54@163.com。
引文格式:黄涛,程康华,顾晓利. 苯并咪唑类化合物的合成及其抑菌活性[J]. 南京林业大学学报:自然科学版,2013,37(2):151-155.
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