基于高压静电技术的戊唑醇/乙酸纤维素缓释剂的制备与性能研究

徐鹏; 高娟; 王利莹; 梁娟; 唐进根

doi:10.3969/j.issn.1000-2006.2016.06.018

徐鹏,高娟,王利莹,梁娟,唐进根

南京林业大学学报（自然科学版） ›› 2016, Vol. 40 ›› Issue (06) : 117-121.

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南京林业大学学报（自然科学版） ›› 2016, Vol. 40 ›› Issue (06) : 117-121. DOI: 10.3969/j.issn.1000-2006.2016.06.018

研究论文

基于高压静电技术的戊唑醇/乙酸纤维素缓释剂的制备与性能研究

徐鹏¹,高娟²,王利莹²,梁娟¹,唐进根^2*

作者信息 +

Preparation and research of tebuconazole-loaded cellulose acetate slow-release formulation by high voltage electrostatic technology

XU Peng¹,GAO Juan²,WANG Liying²,LIANG Juan¹,TANG Jingen^2*

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摘要

以戊唑醇(TBA)为模型药物,可生物降解的乙酸纤维素(CA)为载体材料,利用高压静电技术,制备了载药微球和载药纳米纤维缓释剂,并对载药微球和载药纳米纤维的释放过程进行了研究,同时采用扫描电子显微镜、红外光谱仪对载药微球和载药纳米纤维的结构和形貌进行了表征。结果表明,在缓释剂制备过程中,CA溶液浓度对载药缓释剂的形貌有较大的影响,CA溶液质量分数为4%时,制得的缓释剂为球形结构; CA溶液质量分数为15%时,制得的缓释剂为纳米纤维结构。载药微球和载药纳米纤维均具有一定的缓释性能,对白色念珠菌具有明显的抗菌效果。

Abstract

In this paper, the tebuconazole(TBA)was loaded on the cellulose acetate(CA)that is one of the biodegradable materials.The TBA-loaded microspheres and nano-fibers slow-release agents were prepared using the high voltage electrostatic technology. The release processes of the TBA-loaded microspheres and nano-fibers were also investigated. The structures and morphologies of the TBA-loaded microspheres and nano-fibers were characterized by the scanning electron microscopy, infrared spectrometer and laser particle size analyzer. Research results indicated that the concentration of cellulose acetate solution exerted a great influence on the structure of TBA release systems. The TBA-loaded microspheres were fabricated at a CA concentration of 4%, and the TBA-loaded nano-fibers were made at a CA concentration of 15%. Both the TBA-loaded microspheres and nano-fibers showed the slow-release property, and exerted definite antibacterial effect on the Candida albicans.

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徐鹏,高娟,王利莹,梁娟,唐进根. 基于高压静电技术的戊唑醇/乙酸纤维素缓释剂的制备与性能研究[J]. 南京林业大学学报（自然科学版）. 2016, 40(06): 117-121 https://doi.org/10.3969/j.issn.1000-2006.2016.06.018

XU Peng,GAO Juan,WANG Liying,LIANG Juan,TANG Jingen. Preparation and research of tebuconazole-loaded cellulose acetate slow-release formulation by high voltage electrostatic technology[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY. 2016, 40(06): 117-121 https://doi.org/10.3969/j.issn.1000-2006.2016.06.018

中图分类号： S767

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基金

基金项目:江苏省自然科学基金(青年基金)项目(BK20130969)
第一作者:徐鹏(xupeng@njfu.edu.cn)。
*通信作者:唐进根(xupeng5993@126.com),副教授,博士。
引文格式:徐鹏,高娟,王利莹,等. 基于高压静电技术的戊唑醇/乙酸纤维素缓释剂的制备与性能研究[J]. 南京林业大学学报(自然科学版),2016,40(6):117-121.