植物病原真菌聚酮类次级代谢产物研究进展

苏胜荣; 陈凤毛; 李欢; 王立超

doi:10.12302/j.issn.1000-2006.202405014

植物病原真菌聚酮类次级代谢产物研究进展

苏胜荣, 陈凤毛, 李欢, 王立超

南京林业大学学报（自然科学版） ›› 2025, Vol. 49 ›› Issue (4) : 285-292.

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南京林业大学学报（自然科学版） ›› 2025, Vol. 49 ›› Issue (4) : 285-292. DOI: 10.12302/j.issn.1000-2006.202405014

综合述评

植物病原真菌聚酮类次级代谢产物研究进展

苏胜荣 ¹^,² ,
陈凤毛 ²^,^* ,
李欢 ² ,
王立超 ²

作者信息 +

Research progress on the polyketone secondary metabolites from phytopathogenic fungi

SU Shengrong ¹^,² ,
CHEN Fengmao ²^,^* ,
LI Huan ² ,
WANG Lichao ²

Author information +

文章历史 +

摘要

在植物与病原真菌相互作用过程中,病原真菌通过产生次级代谢产物协助其对植物的入侵和致病。由聚酮合酶(polyketide synthase, PKS)参与合成的真菌聚酮类化合物是真菌中最丰富的次级代谢产物,通过合成重要的色素、致病因子和真菌毒素帮助病原真菌逃避和破坏寄主植物的免疫机制,从而成功侵染。笔者综述了真菌Ⅰ型聚酮合酶多功能域重复串联催化的结构特点;独立及偶联其他酶类催化基因簇合成包括真菌毒素、抗生素和色素在内的多种化合物,赋予真菌发育、抗逆和致病等诸多功能;总结了转录因子、表观遗传学修饰和次级代谢通路对聚酮化合物合成的调控方式;着重列举近年来主要植物病原真菌聚酮类产物及其合成基因簇;并对真菌聚酮类次级代谢产物调控网络解析、合成生物学和产物鉴定等研究方向进行展望。通过分析以期为揭示病原真菌致病机制和植物真菌病害的防控提供研究思路和策略。

Abstract

During host-pathogen interaction, pathogenic fungi facilitate host invasion and pathogenesis through the production of secondary metabolites. Fungal polyketides, catalyzed by polyketide synthase (PKS), represent the most abundant class of bioactive metabolites in fungi, they can establish phytopathogenic fungi successful infections, by synthesizing key pigments, virulence factors, and mycotoxins to evade and disrupt host plant immune mechanisms. This review systematically examines the structural characteristics, classification, biological functions, and metabolic regulation of fungal type Ⅰ PKS. Furthermore, we highlight recent advances in characterizing polyketide compounds and their biosynthetic gene clusters in plant-pathogenic fungi. Potential future research directions for fungal polyketides are prospected, with emphasis on their role in fungal pathogenicity. Collectively, this work aims to provide novel insights and methodological frameworks for elucidating pathogenic mechanisms of fungal infections and developing targeted disease control strategies.

导出引用

苏胜荣, 陈凤毛, 李欢, 等. 植物病原真菌聚酮类次级代谢产物研究进展[J]. 南京林业大学学报（自然科学版）. 2025, 49(4): 285-292 https://doi.org/10.12302/j.issn.1000-2006.202405014

SU Shengrong, CHEN Fengmao, LI Huan, et al. Research progress on the polyketone secondary metabolites from phytopathogenic fungi[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY. 2025, 49(4): 285-292 https://doi.org/10.12302/j.issn.1000-2006.202405014

中图分类号： S432.1;S763

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