载Fe3O4纳米粒子磁性PLA微囊的制备

doi:10.3969/j.issn.1000-2006.2015.04.017

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南京林业大学学报（自然科学版） ›› 2015, Vol. 39 ›› Issue (04): 101-104.doi: 10.3969/j.issn.1000-2006.2015.04.017

载Fe₃O₄纳米粒子磁性PLA微囊的制备

徐鹏¹,陈懿玺¹,唐进根²,曹小勇³,张蕤^1*

1.南京林业大学化学工程学院,江苏南京 210037;
2. 南京林业大学林学院,江苏南京 210037;
3. 南京市产品质量监督检验院,江苏南京 210028

出版日期:2015-07-31 发布日期:2015-07-31
基金资助:
收稿日期:2014-05-09 修回日期:2014-10-11基金项目:江苏省基础研究计划项目(BK20130969); 江苏高校优势学科建设工程资助项目(PAPD); 2013年南京林业大学大学生实践创新训练计划项目第一作者:徐鹏,讲师。*通信作者:张蕤,教授。E-mail:zhangrui@njfu.edu.cn。引文格式:徐鹏,陈懿玺,唐进根,等. 载Fe₃O₄纳米粒子磁性PLA微囊的制备[J]. 南京林业大学学报:自然科学版,2015,39(4)

Preparation of magnetic poly lactic acid microcapsules entrapped by Fe₃O₄ nanoparticles

XU Peng¹, CHEN Yixi¹, TANG Jin’gen², CAO Xiaoyong³, ZHANG Rui^1*

1. College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China;
2. College of Forestry, Nanjing Forestry University, Nanjing 210037, China;
3. Nanjing Institute of Product Quality Inspection, Nanjing 210028, China

Online:2015-07-31 Published:2015-07-31

摘要/Abstract

摘要： 以聚乳酸为壁材,利用超声乳化同W1/O/W2复乳化方法相结合的方法,设计合成囊壁载有油溶性Fe₃O₄纳米粒子的磁性中空聚乳酸微囊。扫描电子显微镜分析(SEM)显示微囊外表面光滑,平均直径为1 μm; 透射电子显微镜(TEM)分析显示微囊中空结构明显,Fe₃O₄纳米粒子集中分布于囊壁结构。采用热重分析法(TGA)测定磁性微囊中Fe₃O₄质量分数高达12%。制得的磁性微囊具有较好的复溶性,在水溶液中能稳定分散,并具有较好的磁响应性,可望成为一种有效的磁靶向给药载体材料。

Abstract: The biodegradable magnetic poly lactic acid(PLA)microcapsules with Fe₃O₄ nanoparticles in the wall were designed and prepared based on the combination of ultrasonic emulsification technique and double emulsion-solvent evaporation method. Fe₃O₄ nanoparticles were prepared by coprecipitation method, and coated with undecylenic acid and oleic acid to improve its stability in dichloromethane. The structure and morphology of the magnetic PLA microcapsules were analyzed by scanning electron microcopy(SEM)and transmission electron microscopy(TEM). Moreover, the thermal properties of the magnetic PLA microcapsules were measured by thermogravimetric analysis(TGA). As demonstrated by experimental results, the diameter of the uniform magnetic microcapsules was about 1 μm, and the magnetic PLA microcapsules could be easily separated from aqueous solution by an external magnetic field.

中图分类号:

TQ450.4⁺2

徐鹏,陈懿玺,唐进根,等. 载Fe₃O₄纳米粒子磁性PLA微囊的制备[J]. 南京林业大学学报（自然科学版）, 2015, 39(04): 101-104.

XU Peng, CHEN Yixi, TANG Jin’gen, CAO Xiaoyong, ZHANG Rui. Preparation of magnetic poly lactic acid microcapsules entrapped by Fe₃O₄ nanoparticles[J].Journal of Nanjing Forestry University (Natural Science Edition), 2015, 39(04): 101-104.DOI: 10.3969/j.issn.1000-2006.2015.04.017.

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载Fe₃O₄纳米粒子磁性PLA微囊的制备

Preparation of magnetic poly lactic acid microcapsules entrapped by Fe₃O₄ nanoparticles

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