Abstract: 【Objective】We aimed to understand the correlation and the variation in the content of active compounds [flavonoids, soluble sugar, protein and phenylalanine ammonia-lyase(PAL)] of Ginkgo biloba L.(ginkgo)leaves from 10 different regions.【Method】Their active compounds determined, geographic sources and individual variations were analyzed.【Result】Under the same environmental conditions, the bioactive contents of ginkgo leaves differed significantly among the 10 regions. The average flavonoids, soluble sugar, protein content and PAL activity of plants from the 10 ginkgo-growing regions were 9.13 mg/g, 157.15 mg/g, 0.71 g/L and 10.96 U/g, respectively. Ginkgo flavonoid content was positively correlated with soluble sugar conten and PAL activity, whereas soluble sugar and protein content were significantly negatively correlated.【Conclusion】Ginkgo from the Hanzhong region had the highest flavonoid content, which should be noted for future sourcing of ginkgo. The variation coefficients for flavonoids in the Duyun region was the largest; thus, more attention must be paid to individual selection from among and within regions.