脱氢枞胺(4羟基)水杨醛Schiff碱β环糊精包合物的制备与表征征

征陈泳; 林中祥; 张丹红

doi:10.3969/j.jssn.1000-2006.2011.01.014

征陈泳，林中祥，张丹红

南京林业大学学报（自然科学版） ›› 2011, Vol. 35 ›› Issue (01) : 62-66.

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南京林业大学学报（自然科学版） ›› 2011, Vol. 35 ›› Issue (01) : 62-66. DOI: 10.3969/j.jssn.1000-2006.2011.01.014

研究论文

脱氢枞胺(4羟基)水杨醛Schiff碱β环糊精包合物的制备与表征征

征陈泳，林中祥，张丹红

作者信息 +

Characterization and preparation of dehydroabietylamine 4hydroxysalicylidene Schiff base βcyclodextrin inclusion complex

CHEN Yong, LIN Zhongxiang, ZHANG Danhong

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摘要

采用饱和溶液法制备了脱氢枞胺(4羟基)水杨醛Schiff碱β环糊精包合物，通过红外光谱、差示扫描量热法(DSC)以及紫外光谱对包合物进行鉴定，并对脱氢枞胺(4羟基)水杨醛Schiff碱及其包合物的抗癌活性进行了研究。结果表明：脱氢枞胺(4羟基)水杨醛Schiff碱和环糊精可形成摩尔比为1∶1的包合物; β环糊精可以将脱氢枞胺(4羟基)水杨醛Schiff碱在混合溶剂(V(DMSO)∶V（H2O）=1∶1)中的溶解度提高34倍; 在质量浓度为10 μg/mL时，脱氢枞胺(4羟基)水杨醛Schiff碱及其包合物对卵巢癌细胞株(Hey1B)的抑制率分别达到5034 %和4165 %。

Abstract

Dehydroabietylamine 4hydroxysalicylidene Schiff base complexes enwrapped with βcyclodextrin were prepared by the method of saturation solution, and were identified with IR, DSC and UV. The antitumor activities of the dehydroabietylamine 4hydroxysalicylidene Schiff base and the inclusion complexes were studied. The main results were as follows: The inclusion complex was formed at the 1∶1 molar ratio of dehydroabietylamine 4hydroxysalicylidene Schiff base and βcyclodextrin; the solubility of dehydroabietylamine 4hydroxy salicylidene Schiff base in mixed solvent (V(DMSO)∶V(H2O)=1∶1) was increased by 34 folds after complexing with βcyclodextrin; the inhibitory ratios of the dehydroabietylamine 4hydroxysalicylidene Schiff base and its inclusion complex on ovarian cancer cell line (Hey1B) were 5034% and 4165 %, respectively, at the concentration of 10 μg/mL.

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征陈泳，林中祥，张丹红. 脱氢枞胺(4羟基)水杨醛Schiff碱β环糊精包合物的制备与表征征[J]. 南京林业大学学报（自然科学版）. 2011, 35(01): 62-66 https://doi.org/10.3969/j.jssn.1000-2006.2011.01.014

CHEN Yong, LIN Zhongxiang, ZHANG Danhong. Characterization and preparation of dehydroabietylamine 4hydroxysalicylidene Schiff base βcyclodextrin inclusion complex[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY. 2011, 35(01): 62-66 https://doi.org/10.3969/j.jssn.1000-2006.2011.01.014

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