利用DOE(Design of Experiment)实验设计方法中的Plackett-Burman和全因子设计方法,采用乳液聚合法,以酶转化淀粉作为乳化剂,以聚苯乙烯、丙烯酸和丙烯酸丁酯作为单体合成纸张表面施胶剂。结果表明：引发剂用量（A）、反应温度（B）、滴加时间（C）以及单体用量与反应温度的交互作用（AC）是影响成纸表面强度的关键因子;建立了纸张表面强度(S)与各关键因子之间的数学模型：S=-17375 0+196259A+15B+48375 0C-4125AC,并对数学模型进行了验证。最佳合成条件为:淀粉酶反应温度80 ℃，淀粉酶反应时间10 min，淀粉与单体质量比为1〖DK〗∶1，丙烯酸的质量分数为2 ％，单体苯乙烯与丙烯酸丁酯质量比为6〖DK〗∶1，引发剂H2O2与FeSO4质量比为1〖DK〗∶1。合成表面施胶剂的固含量（质量分数）为2613 %，黏度为283 mPa〖DK〗·s,玻璃化温度为7072 ℃。

Emulsion polymerization was adopted to synthesize the surface sizing agent with polystyrene,acrylic acid, butyl acrylate as monomers and enzymeconverted starch as a emulsifier, using PlackettBurman and total divisor design as the design of experiment(DOE). The results showed that dosage of evocation agent(A), reaction temperature(B), charging time(C) and the interaction(AC) between dosage of evocation agent and titration time were the key factors affecting the surface strength(S) of paper. The relationship among them was expressed with a mathematics model:S=-17375 0+196259A+15B+48375 0C-4125AC and the experiment confirmed its correct ness. The optimum reaction conditions of enzyme was 80 ℃,10 min and the mass ratio of it to monomer quality was 1〖DK〗∶1. The optimum synthesis condition was 2 ％ acrylic acid,the ratio of polystyrene to butyl acrylate 6〖DK〗∶1 and the mass ratio of H2O2 to FeSO4 1〖DK〗∶1. The surface sizing agents solid content was 2613 ％, viscosity was 283 mPa〖DK〗·s and the glass transition temperature was 7072 ℃.