Abstract: Isobornyl methacrylate was synthesized by direct esterification of camphene and methacrylic acid. The synthesis conditions of isobornyl methacrylate were discussed. Effects including reaction time, reaction temperature, molar ratio of camphene to methacrylic acid, types of catalysts and their dosage, types of antipolymerization inhibitors and their dosage on yield and selectivity were investigated. The optimum conditions were obtained by orthogonal test. The optimum conditions were 10% Amberlyst 15 as the catalyst(based on total mass of reactants percent), 0.03% phenothiazine as the polymerization inhibitor, the molar ratio of methacrylic acid to camphene 1.3:1, esterification temperature 60 ℃, reaction time 8-9 h. The average yield and the selectivity of isobornyl methacrylate under the optimum conditions were 80.2% and 95.3% respectively, and the ester content was more than 99.2%. The structure of the isobornyl acrylate was analyzed by GC-MS, FT-IR and so on.