同源四倍体自然群体的连锁不平衡分析模型

冯思思; 王建新; 庞晓明; 邬荣领

doi:10.3969/j.issn.1000-2006.2014.04.006

同源四倍体自然群体的连锁不平衡分析模型

冯思思,王建新,庞晓明,邬荣领

南京林业大学学报（自然科学版） ›› 2014, Vol. 38 ›› Issue (04) : 29-33.

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南京林业大学学报（自然科学版） ›› 2014, Vol. 38 ›› Issue (04) : 29-33. DOI: 10.3969/j.issn.1000-2006.2014.04.006

研究论文

同源四倍体自然群体的连锁不平衡分析模型

冯思思¹,王建新^1,2, 庞晓明¹, 邬荣领^1*

作者信息 +

A model for linkage disequilibrium analysis in an autotetraploid natural population

FENG Sisi¹, WANG Jianxin^1,2, PANG Xiaoming¹, WU Rongling^1*

Author information +

文章历史 +

摘要

半数以上的被子植物是多倍体或在其进化史上出现过多倍体现象,连锁不平衡分析是研究自然群体遗传结构、分化及多样性的重要工具,但这一方法目前仅适用于二倍体自然群体。笔者根据同源四倍体减数分裂的特点推导出计算分子标记间连锁不平衡的统计模型,利用基因频率和基因型频率的关系,以计算机模拟试验验证了模型的有效性,并给出了模型的适用条件,即样本数量为200时,采用该模型估算的平均值可以满足分析要求。

Abstract

More than 50% of angiosperms are polyploidy, or have experienced genome doubling in their evolutionary history. Thus, polyploids provide a valuable tool to study the genetics and evolution of plants. Linkage disequilibrium analysis has been widely used to infer the genetic structure, differentiation and diversity of natural populations, but its basic principle was found on a diploid population. In this article, we have derived a model for linkage disequilibrium analysis between a pair of molecular markers for the first time based on meiotic properties of autotetraploids. Computer simulation has been performed to examine the usefulness of the new model and determine the condition of its utilization.

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冯思思,王建新,庞晓明,邬荣领. 同源四倍体自然群体的连锁不平衡分析模型[J]. 南京林业大学学报（自然科学版）. 2014, 38(04): 29-33 https://doi.org/10.3969/j.issn.1000-2006.2014.04.006

FENG Sisi, WANG Jianxin, PANG Xiaoming, WU Rongling. A model for linkage disequilibrium analysis in an autotetraploid natural population[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY. 2014, 38(04): 29-33 https://doi.org/10.3969/j.issn.1000-2006.2014.04.006

中图分类号： S722

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基金

收稿日期:2013-12-30 修回日期:2014-03-19
基金项目:国家林业公益性行业科研专项项目(201404102)
第一作者:冯思思,硕士生。*通信作者:邬荣领,教授。E-mail: rwu@phs.psu.edu; rwu@bjfu.edu.cn。
引文格式:冯思思,王建新, 庞晓明,等. 同源四倍体自然群体的连锁不平衡分析模型[J]. 南京林业大学学报:自然科学版,2014,38(4):29-33.