Abstract: The confluence area of Hung-tse Lake and Huaihe River is one of the most important wetland types, which is functionally serving as the particular biology resource reservoir and buffer zone. To understand the wetland evolution and the driving factors as well as changes of the land use in Laozishan town(118.454°-118.692°E,33.166°-33.188°N), a typical wetland was investigated at the intersection place of Hung-tse Lake and Huaihe River. The land use information was extracted from three sets of remote sensing images data(2003, 2008 and 2013)with high resolution and land use spatial distribution during the past 10 years. The spatial and temporal changes in the conversion of land use, variation tendency and driving factors were analyzed by GIS technique, transfer matrix and centroid method. The results showed: ①The open water dominated the regional land use. The areas of emergent plant, culture ponds and farmlands increased with time going while the areas of the open water, trees and shrubs decreased during the past 10 years. ②An area of 2 959.57 hm² open water has been converted as emergent plant(1 535.15 hm²), culture ponds(984.09 hm²)and trees and shrubs(440.33 hm²), respectively. In contrast, the areas of open water, culture ponds and emergent plant have increased to 1 711.72, 503.69 and 482.71 hm² during the period, respectively. ③The centroid of trees and shrubs in the region wholly extended to the open water in the northwest, while the distribution of the emergent plant shifted to the northeast, showing a rapid expansion to the downstream. Both farmlands and culture ponds have expanded from the western developed shoals to the eastern developing shoals. It could be concluded that culture ponds substantially lead to an increasing landscape fragment, thus threatening the ecological functions of the wetlands. It is very urgent for the wetland protection to conduct the potential countermeasures in the next activities.