三唑类化合物的合成及抑菌活性

doi:10.3969/j.issn.1000-2006.2014.02.031

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南京林业大学学报（自然科学版） ›› 2014, Vol. 38 ›› Issue (02): 161-164.doi: 10.3969/j.issn.1000-2006.2014.02.031

三唑类化合物的合成及抑菌活性

燕乐乐¹,刘幸平^1*,程康华²,李靖¹

1.南京中医药大学药学院,江苏南京 210046;
2.南京林业大学化学工程学院,江苏南京 210037

出版日期:2014-03-10 发布日期:2014-03-10
基金资助:
收稿日期:2013-06-08 修回日期:2013-09-24
基金项目:国家林业公益性行业科研专项项目(201104032)
第一作者:燕乐乐,硕士生。*通信作者:刘幸平,教授。E-mail: xpliu1955@163.com。。
引文格式:燕乐乐,刘幸平,程康华,等. 三唑类化合物的合成及抑菌活性[J]. 南京林业大学学报:自然科学版,2014,38(2):161-164.

Synthesis of triazole compounds and evaluation of their antimicrobial activities

YAN Lele¹,LIU Xingping^1*,CHENG Kanghua²,LI Jing¹

1.College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046,China;
2.College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037,China

Online:2014-03-10 Published:2014-03-10

摘要/Abstract

摘要： 为了获得高活性的木材防腐剂,以1,3-二氯苯为原料,依次经过傅克酰基化、烷基化、环氧化及开环反应得到6种三唑类化合物Y-4(a-f),且所有化合物的结构经过MS和¹H-NMR确定; 采用滤纸片法对常见的两种霉菌和两种木腐菌进行活性抑菌实验。结果表明:6种化合物中,Y-4d表现出的抗菌谱较广,对木材霉菌和腐朽菌都有抑制作用,但对腐朽菌的抑制效果不如Y-4c和Y-4f,Y-4c和Y-4f对木材腐朽菌表现出较强的抑制能力。

Abstract: In order to get a wood preservative with higher efficiency, six compounds Y-4(a-f)were synthesized using 1, 3-dichlorobenzene as the starting material by Friedel-crafts acetylation, alkylation, epoxidation, and ring-opening reaction. The structures of these compounds were determined by MS and ¹H-NMR. Antifungal activities of these compounds were evaluated by two moulds and two decay fungi with Filter paper diffusion. The results indicated that Y-4d had a broad spectrum of antibacteria on moulds and decay fungi, but Y-4c and Y-4f had better antibacterial effect on decay fungi.

中图分类号:

S482.2

燕乐乐,刘幸平,程康华,等. 三唑类化合物的合成及抑菌活性[J]. 南京林业大学学报（自然科学版）, 2014, 38(02): 161-164.

YAN Lele,LIU Xingping,CHENG Kanghua,LI Jing. Synthesis of triazole compounds and evaluation of their antimicrobial activities [J].Journal of Nanjing Forestry University (Natural Science Edition), 2014, 38(02): 161-164.DOI: 10.3969/j.issn.1000-2006.2014.02.031.

参考文献

[1] 杨光富,杨华铮.麦角甾醇生物合成抑制剂分子设计的研究进展[J].农药译丛, 1996(1):21-29. Yang G F, Yang H Z. The development on molecular designing of ergosterol biosynthesis inhibitors[J]. Translated Collection of Pesticide,1996(1):21-29.
[2] 杨利.麦角甾醇生物合成抑制剂的合成和抑菌活性的研究[D].杨凌:西北农林科技大学,2008. Yang L. Study on synthesis and antibacterial activity of ergosterol biosynthesis inhibitors[D].Yangling: Northwest Agriculture and Forestry University,2008.
[3] 杜英娟. 国外杀菌剂的发展近况[J].农药,1989,28(1):48-51. Du Y J. The development of foreign fungicide[J]. Pesticide,1989,28(1):48-51.
[4] 李煜昶,石素娥.多效唑新合成方法的研究[J].农药,1994,33(4):19-20. Li Y C, Shi S E.Study on new synthesis methods of MET[J]. Pesticide,1994,33(4):19-20.
[5] 许良忠. 三唑类P450-DM抑制剂的合成、表征及生物活性研究[D].青岛:中国海洋大学,2004. Xu L Z.Studies on the synthesis, characterization and biological activities of P450-14DM inhibitors[D]. Qingdao:Ocean University of China,2004.
[6] Acda M N, Morrell J J, Levien K L. Supercritical fluid impregnation of selected wood species with Tebuconazole[J]. Wood Science and Technology, 2001, 35(1-2):127-136.
[7] Acda M N, Morrell J J, Levien K L. Effect of process variable on supercritical fluid impregnation of composites with tebuconazole [J]. Wood Fiber Science, 1997, 29(3):282-290.
[8] Acda M N, Morrell J J, Levien K L.Effects of SCF treatments on physical properties of wood-based composites[J]. Wood Fiber Science, 1997, 29(2):121-130.
[9] Muin M, Adachi A,Lnoue M, et al. Feasibility of supercritical carbon dioxide as a carrier solvent for preservative treatment of wood-based composites[J]. Journal of Wood Science, 2003, 49(1):65-72.
[10] 王健祥. 氟康唑的新合成工艺研究[J].中国现代应用药学杂志,2006,23(1):35-37. Wang J X. Study on the new preparation of fluconazole[J]. China M A P,2006,23(1):35-37.
[11] Richardson. Antifungal 1,3-bis-triazoly-2-propanolderivative U.S.,440216[P]:1983-09-13.
[12] 吴春丽,李幸,施绣芳.氟康唑的合成工艺研究及优化[J].中国药物化学杂志,2001, 21(4):304-307. Wu C L, Li X,Shi X F. Study on synthesis and optimization of fluconazole[J].Chinese Journal of Medicinal Chemistry,2001,21(4):304-307.
[13] 张玲.银杏树木提取物对木材防腐作用的研究[D]. 南京:南京林业大学, 2009. Zhang L. Study on the effect of extraction of gingko on wood preservation[D]. Nanjing:Nanjing Forestry University,2009.
[14] 黄涛,程康华,顾晓丽.苯并咪唑类化合物的合成及其抑菌活性[J].南京林业大学学报:自然科学版,2013,7(2):151-155. Huang T,Cheng K H,Gu X L. Synthesis and bacteriostatic activity of benzimidazole compounds[J].Journal of Nanjing Forestry University:Natural Sciences Edition, 2013,7(2):151-155.
[15] 李靖,刘幸平,程康华,等.三唑类杀菌剂的合成工艺及其抑菌性评价[J].木材工业,2013, 27(3):21-24. Li J,Liu X P, Cheng K H, et al. Synthesis and bacteriostasis of triazole compound[J].China Wood Industry,2013,27(3):21-24.
[16] 钟武,张万年,李科,等.2',4'-二氟-α(1H-1,2,4-三唑-1-基)苯乙酮的合成[J].中国医药工业杂志,1999,30(9):418. Zhong W, Zhang W N,Li K, et al. Synthesis of 2',4'-difluoro-α-(1H-1,2,4-triazol-1-yl)acetophenon[J]. Chinese Journal of Phar Maceuticals 1999,30(9):418.

三唑类化合物的合成及抑菌活性

Synthesis of triazole compounds and evaluation of their antimicrobial activities

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