乳化喷雾干燥法制备戊唑醇/壳聚糖微胶囊

徐鹏; 王利莹; 曹小勇; 邵伟; 唐进根

doi:10.3969/j.issn.1000-2006.201608005

乳化喷雾干燥法制备戊唑醇/壳聚糖微胶囊

徐鹏,王利莹,曹小勇,邵伟,唐进根

南京林业大学学报（自然科学版） ›› 2017, Vol. 41 ›› Issue (03) : 157-161.

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南京林业大学学报（自然科学版） ›› 2017, Vol. 41 ›› Issue (03) : 157-161. DOI: 10.3969/j.issn.1000-2006.201608005

研究论文

乳化喷雾干燥法制备戊唑醇/壳聚糖微胶囊

徐鹏¹,王利莹²,曹小勇³,邵伟¹,唐进根^2*

作者信息 +

Fabrication of tebuconazole/chitosan microcapsules by the method of spray-drying

XU Peng¹, WANG Liying², CAO Xiaoyong³, SHAO Wei¹,TANG Jingen^2*

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文章历史 +

摘要

【目的】以壳聚糖(CS)为壁材,杀菌农药戊唑醇(TBA)为芯材,采用乳化喷雾干燥法制备出载戊唑醇/壳聚糖(TBA/CS)微胶囊制剂。【方法】通过扫描电子显微镜探讨了乳液组成(水油比)和喷雾干燥条件对TBA/CS微胶囊结构和形貌的影响,并通过模拟释放实验研究了TBA/CS微胶囊的缓释性能。【结果】当CS溶液质量分数为1.2%,表面活性剂质量分数为1.1%,喷雾气体压力为4 bar(400 kPa),进料速度10.5 m³/h时,制得的TBA/CS微胶囊有规整的球形结构,且具有良好的缓释性能,对白色念珠菌具有明显的抑菌效果。【结论】乳化喷雾干燥法制备载戊唑醇/壳聚糖(TBA/CS)微胶囊的方法简单,CS溶液浓度、表面活性剂浓度、喷雾气体压力、进料速度等实验条件对制备的TBA/CS微胶囊形貌有较大的影响。

Abstract

【Objective】 In this study, tebuconazole/chitosan microcapsules were prepared by the method of spray-drying. Chitosan was chosen as wall material, and tebuconazole was chosen as core material during the preparation of microcapsules. 【Methed】 The effection of the composition of emulsion(ratio of water to oil)and conditions of spray drying to the morphology of microcapsules have been discussed by scanning electron microscope(SEM), and the release of the tebuconazole/chitosan microcapsules has been researched by simulating experiment. 【Result】 The results showed that the concentration of chitosan solution, the concentration of surfactant, the compressed gas flow rate, and the feed rate all have great influence on the morphology of microcapsules. 【Conclusion】 The method of spray-drying to prepare the tebuconazole/chitosan microcapsules is simple. Tebuconazole/chitosan microcapsules with regular spherical morphology have been fabricated when Tween-80 were used as compound emulsifiers with the concentration of 1.1%(w/w), the concentration of chitosan was 1.2%(w/w), the compressed gas flow rate for spray-drying was 4 bar(400 kPa), and the feed rate for spray-drying was 10.5 m³/h. Moreover, these microcapsules showed a good-release performance and an obvious antibacterial activity against Candida albicans.

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徐鹏,王利莹,曹小勇,邵伟,唐进根. 乳化喷雾干燥法制备戊唑醇/壳聚糖微胶囊[J]. 南京林业大学学报（自然科学版）. 2017, 41(03): 157-161 https://doi.org/10.3969/j.issn.1000-2006.201608005

XU Peng, WANG Liying, CAO Xiaoyong, SHAO Wei,TANG Jingen. Fabrication of tebuconazole/chitosan microcapsules by the method of spray-drying[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY. 2017, 41(03): 157-161 https://doi.org/10.3969/j.issn.1000-2006.201608005

中图分类号： TQ450.45

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基金

收稿日期:2016-08-03 修回日期:2017-03-16
基金项目:江苏省自然科学基金项目(BK20130969)
第一作者:徐鹏(xupeng@njfu.edu.cn),副教授,博士。*通信作者:唐进根(tangjingen@njfu.com.cn),副教授,博士。
引文格式:徐鹏,王利莹,曹小勇,等. 乳化喷雾干燥法制备戊唑醇/壳聚糖微胶囊[J]. 南京林业大学学报(自然科学版),2017,41(3):157-161.