Abstract: This paper provided a new method via manufacturing a new self-cleaning and covering material coated with nano-sized TiO2 photo-catalysis. However, it was unknown what would happen if the melamine formaldehyde (MF) resin matrix was mixed with strong oxidative nano- sized TiO2. It was found that anatase nano-sized TiO2 had a lot of hydroxyl groups on the surface, and no new functional groups of mixture of MF/TiO2 were detected by infrared spectroscopy (IR). In terms of covering materials coated with TiO2, electron spin resonance (ESR) proved that it still had catalytic capability even two months later once it was exposed under UV lights.