Abstract: In order to guide safe use of pesticides scientifically and make a guideline for using propargite on mulberry safely, the dissipation and final residue characteristics of propargite in different parts of mulberry were explored. The method of liquid chromatography tandem mass spectrometry was conducted to study the residue characteristics in different days after propargite was used and its final residue under different treatments. The results showed that the propargite residue in different parts of mulberry follow the one- order kinetics equations C=C₀e^-kt. According to the one-order kinetic equations, the half lives of propargite reside in foliage, soil and fruit of mulberry were 6.78- 10.42, 9.21-12.46 and 7.91-10.85 d, respectively. The final residue study showed that the residues of foliage, fruit and soil of mulberry at 10 days after propargite use were 16.7%-30.40%, 29.0%-31.1% and 37.1% -34.7% of that at 3 days after use, respectively. The final residues in foliage and fruit of mulberry were both lower than 10.0 mg/kg at 10 days after using propargite. It is recommended that the MRL in mulberry may be suggested to set at 10.0 mg/kg, the maximum application times were below 2 times and the preharvest interval in mulberry was set at 10 days.