Abstract: Gleditsia sinensis Lam. is a good species for restoring ecoenvironment in Karst region of Qianzhong area. The soil enzymes activities （invertase， urease， polyphenol oxidase and catalase） in six different lithological soils （quartz sandstone， metamorphosed sandstone， quaternary red clay， coalbearing sandstone and shale， purple sandstone and shale， gray dolomite） under Chinese honey locus planting were studied.The results showed that： Invertase activity in six rock soils weakened with the growing season changed（initial stage， vigorous stage of growth and end stage of growth）， urease activity was enhanced with the growing season， polyphenol oxidase and catalase activity changed little. Soil enzyme activity was different in six soils. Invertase activity in sandstone was the strongest， and quartz was the weakest in the early stage. There were little differences in mid growth among six sort of soils. Invertase activity in shale gray dolomite was the strongest； urease activity was weakest in quartz sandstone and change over sandstone and there were no significant differences among the other four soils.Catalase activity was highest in shale， and gray dolomite.Soil enzyme activity and soil nutrient content were significantly correlated during three growing seasons of Chinese honey locus. Compared with the relationship of the soil enzyme activities to the growth of Chinese honey locus， the gray dolomite is good for Chinese honey locus. This result provided the theory basis for forest vegetation restoration and tree selection in Karst region of Guizhou province.