苯并咪唑类化合物的合成及其抑菌活性

doi:10.3969/j.issn.1000-2006.2013.02.027

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南京林业大学学报（自然科学版） ›› 2013, Vol. 37 ›› Issue (02): 151-155.doi: 10.3969/j.issn.1000-2006.2013.02.027

苯并咪唑类化合物的合成及其抑菌活性

黄涛,程康华^*,顾晓利

南京林业大学化学工程学院,江苏南京 210037

出版日期:2013-04-18 发布日期:2013-04-18
基金资助:
收稿日期:2012-02-19 修回日期:2012-10-10
基金项目:国家林业公益性行业科研专项项目(201104032)
第一作者:黄涛,硕士生。*通信作者:程康华,教授。E-mail: chengkh54@163.com。
引文格式:黄涛,程康华,顾晓利. 苯并咪唑类化合物的合成及其抑菌活性[J]. 南京林业大学学报:自然科学版,2013,37(2):151-155.

Synthesis and bacteriostatic activity of benzimidazole compounds

HUANG Tao,CHENG Kanghua^*,GU Xiaoli

College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

Online:2013-04-18 Published:2013-04-18

摘要/Abstract

摘要： 为探索具有高活性的有机木材防腐剂,以4-取代邻苯二胺为原料,经酰化、环合等步骤合成了7种5-取代苯并咪唑类衍生物,并经熔点、MS、¹H-NMR及元素分析确证其结构。用滤纸片法研究目标化合物对白腐菌(彩绒革盖菌(Coriolus versicolor))、褐腐菌(密粘褶菌(Gloeophyllum trabeum))、霉菌(黑曲霉(Aspergillus niger)和绿色木霉(Trichoderma viride))的抑制活性,结果表明:合成的7种化合物对木材中的腐朽菌均没有抑菌活性,但部分化合物对木材腐朽菌中的霉菌有明显的抑制效果; 化合物4a在质量分数为1.0%时对两种霉菌就表现出较强的抑菌效果,且其效果明显优于对照试剂(五氯酚钠),化合物4b的抑菌效果则与对照试剂相当。

Abstract: To find new organic wood preservative with broad-spectrum and hyperactivity, seven 5-substituted benzimidazole compounds were synthesized from 4-substituted ο-phenylenediamine through multi-step reactions including acylation, cyclization and so on. Their chemical structures were confirmed by melting points, MS, ¹H NMR and elemental analysis. The target compounds were screened for antimicrobial activity by agar-well diffusion method against white-rot fungi(Coriolus versicolor), brown-rot fungi(Gloeophyllum trabeum)and moulds(Aspergillus niger and Trichoderma viride). The preliminary fungicidal tests showed that seven compounds had no fungicidal activities, but some of them had anti-mould activities. Compound 4a at concentration of 1.0% showed strong anti-mould activity which was significantly higher than that of pentachlorophenate, and compounds 4b was equal to contrast.

中图分类号:

O626

黄涛,程康华,顾晓利. 苯并咪唑类化合物的合成及其抑菌活性[J]. 南京林业大学学报（自然科学版）, 2013, 37(02): 151-155.

HUANG Tao,CHENG Kanghua,GU Xiaoli. Synthesis and bacteriostatic activity of benzimidazole compounds[J].Journal of Nanjing Forestry University (Natural Science Edition), 2013, 37(02): 151-155.DOI: 10.3969/j.issn.1000-2006.2013.02.027.

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苯并咪唑类化合物的合成及其抑菌活性

Synthesis and bacteriostatic activity of benzimidazole compounds

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