Abstract: Landscape ecological quality is an important index to measure the ecological environment. There is greatly significance to study the landscape ecological quality from the angle of landscape ecology. Landscape ecological quality depends on the landscape ecosystem, and landscape ecosystem is influenced by its stability and external interference degree mainly. The evaluation index system was established from the two aspects which are stability and interference degree. Then a comprehensive evaluation model was built to evaluate the landscape ecological quality and its changes in Anhui Province in recent ten years. The results showed that the area of landscape ecological quality as the first class only decreased by 0.84%, and the area of landscape ecological quality as the third class only increased by 0.54% in 2000-2005. But in 2005-2010, the area of landscape ecological quality as the first class decreased by 2.46%, and the area of landscape ecological quality as the third class increased by 4.33%. Which showed that landscape ecological quality of Anhui Province decreased from 2000 to 2005, but the overall situation was still in a stable state. While the landscape ecological quality was in a declining trend from 2005 to 2010.