Research progress on the polyketone secondary metabolites from phytopathogenic fungi

SU Shengrong, CHEN Fengmao, LI Huan, WANG Lichao

JOURNAL OF NANJING FORESTRY UNIVERSITY ›› 2025, Vol. 49 ›› Issue (4) : 285-292.

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南京林业大学学报（自然科学版）
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JOURNAL OF NANJING FORESTRY UNIVERSITY ›› 2025, Vol. 49 ›› Issue (4) : 285-292. DOI: 10.12302/j.issn.1000-2006.202405014

Research progress on the polyketone secondary metabolites from phytopathogenic fungi

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Abstract

During host-pathogen interaction, pathogenic fungi facilitate host invasion and pathogenesis through the production of secondary metabolites. Fungal polyketides, catalyzed by polyketide synthase (PKS), represent the most abundant class of bioactive metabolites in fungi, they can establish phytopathogenic fungi successful infections, by synthesizing key pigments, virulence factors, and mycotoxins to evade and disrupt host plant immune mechanisms. This review systematically examines the structural characteristics, classification, biological functions, and metabolic regulation of fungal type Ⅰ PKS. Furthermore, we highlight recent advances in characterizing polyketide compounds and their biosynthetic gene clusters in plant-pathogenic fungi. Potential future research directions for fungal polyketides are prospected, with emphasis on their role in fungal pathogenicity. Collectively, this work aims to provide novel insights and methodological frameworks for elucidating pathogenic mechanisms of fungal infections and developing targeted disease control strategies.

Key words

filamentous fungi / polyketide / gene cluster / pathogenic function / regulation mechanism

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SU Shengrong , CHEN Fengmao , LI Huan , et al. Research progress on the polyketone secondary metabolites from phytopathogenic fungi[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY. 2025, 49(4): 285-292 https://doi.org/10.12302/j.issn.1000-2006.202405014

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