The coupling stiffness matrix model of unsymmetrical wood based panels was built under the theory of composite materials mechanics. This research discussed the relation between the coupling stiffness coefficient(B11, B22) and the warping of panels, some factors on panels coupling which include:the ply amounts, the order and the alignment of panels. The results showed that the bigger the absolute value of coupling stiffness matrix was, the more the warping of panels were. In the coupling stiffness matrix, the coupling coefficients B11 and B22 had the major effects on panels warping. The structure of unsymmetrical wood based panels could be designed and warping of panels could be reduced through calculating the coupling stiffness matrix B, modifying the ply amounts, the order and the alignment of panels.