Abstract: SCL6 is one of the key genes for plant to maintain the shoot apical meristem tissue in indeterminate state. A homologue gene of SCL6 was cloned from moso bamboo(Phyllostachys edulis Carr.)using RT-PCR and RACE methods, and named as PeSCL6. The full length of PeSCL6 was 1 894 bp including 60 bp 5' untranslated region(UTR), 211 bp 3' UTR and an open reading frame of 1 623 bp, which encoded 489 amino acids. Blastp analysis indicated that PeSCL6 had high identities with SCL6 from monocotyledon plants(all up to more than 70%)such as Zea mays, Oryza sativa and Sorghum bicolor. Real time PCR analysis showed that PeSCL6 expressed constitutively with the highest level in leaves of young seedlings. However, the PeSCL6 expressed much lower in the leaves at adult bamboo at just before and full blooming stages, which were only 1% and 14% of that in young seedling leaves, respectively. The changes of expression level in leaves indicated that PeSCL6 gene might be involved in the switch regulation of moso bamboo from vegetative to reproductive growth.