Study on removing ginkgolic acids from EGb by coordination-organic solvent method

doi:10.3969/j.issn.1000-2006.2015.02.002

JOURNAL OF NANJING FORESTRY UNIVERSITY ›› 2015, Vol. 39 ›› Issue (02): 7-13.doi: 10.3969/j.issn.1000-2006.2015.02.002

Study on removing ginkgolic acids from EGb by coordination-organic solvent method

YANG Shilong¹, HUANG Chunli², TANG Ying³, XU Li^2,3,4*, JIANG Guobin⁵, CAO Fuliang^4,5*, LEI Meng², CHEN Yong², WANG Yanqin²

1. College of Chemical Engineering, Nanjing Forestry University,Nanjing 210037, China;
2. College of Science, Nanjing Forestry University,Nanjing 210037, China;
3.Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing 210037, China;
4. Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China;
5. College of Forestry, Nanjing Forestry University, Nanjing 210037, China

Online:2015-03-31 Published:2015-03-31

Abstract

Abstract: Extracts of Ginkgo biloba (EGb)has many biological activities, however, the existence of ginkgolic acids in EGb limit the applications of EGb. Currently, organic solvent method and column chromatography method are the main ways to remove ginkgolic acids from EGb. As a new method, coordination-organic solvent method was put forward based on organic solvent method. In coordination-organic solvent method,metal ions were added to the mixed solution from the best technological conditions of organic solvent method. The results showed that the coordination-organic solvent method could not only effectively remove ginkgolic acids, but also reduce the extraction times without affecting the content of total flavonoid glycosides and total ginkgolides. Meanwhile, a small amount of flavonoids and zinc ions could form complexes, which could improve the EGb activity of anti-hepatoma cells(HepG2).

CLC Number:

YANG Shilong, HUANG Chunli, TANG Ying, XU Li^2,3,4*, JIANG Guobin, CAO Fuliang^4,5*, LEI Meng, CHEN Yong, WANG Yanqin. Study on removing ginkgolic acids from EGb by coordination-organic solvent method[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY, 2015, 39(02): 7-13.

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Study on removing ginkgolic acids from EGb by coordination-organic solvent method

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