Acute toxicity of proanthocyanidins from Myrica esculenta Buch. Ham. bark on mice and its antioxidative properties

doi:10.3969/j.issn.1000-2006.2013.04.016

JOURNAL OF NANJING FORESTRY UNIVERSITY ›› 2013, Vol. 37 ›› Issue (04): 85-89.doi: 10.3969/j.issn.1000-2006.2013.04.016

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Acute toxicity of proanthocyanidins from Myrica esculenta Buch. Ham. bark on mice and its antioxidative properties

ZHANG Lun, LIU Gongjun, HE Baiqiu, WANG Fei

Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University,Nanjing 210037, China

Online:2013-08-18 Published:2013-08-18

Abstract

Abstract: The security of proanthocyanidins extractive from Myrica esculenta Buch. Ham. was investigated by analyzing its acute toxicity and antioxidative properties in vivo to mice. The results showed that the LD₅₀ of proanthocyanidins extractive from M. esculenta Buch. Ham. bark in mice was 5 g/kg, and the activities of catalase(CAT), superoxide dismutase(SOD)significant increased(p<0.05); the contents of malondialdehyde(MDA)decreased in mice serum. In liver, the activities of CAT increased(p<0.05), the content of MDA increased but was not significant difference with control(p>0.05). Thus, during the acute oral toxicity, the extractive from M. esculenta Buch. Ham. bark did not reveal any toxic effects in ICR mice(data not shown)and have some antioxidative properties in vivo.

CLC Number:

S718.4
TQ91

ZHANG Lun, LIU Gongjun, HE Baiqiu, WANG Fei. Acute toxicity of proanthocyanidins from Myrica esculenta Buch. Ham. bark on mice and its antioxidative properties[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY, 2013, 37(04): 85-89.

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Acute toxicity of proanthocyanidins from Myrica esculenta Buch. Ham. bark on mice and its antioxidative properties

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