Abstract: To reveal the photocatalytic degradation characteristics of ibuprofen(IBP), the effects of adsorption, photolysis, initial concentration, initial pH value and H₂O₂ dosage on the degradation of ibuprofen were explored by photoreactor with immobilized TiO₂ catalyst supported on fiberglass net by solgel method. Mineralization and intermediates were also investigated. Results indicated that adsorption and photolysis under UV365 had little effects on IBP degradation. The degradation of IBP followed pseudlo-first-order kinetics under studied conditions, and the pseudo-first-order kinetic constants decreased with the increase of initial concentration. The photocatalytic degradation rate decreased with the increase of initial pH, for that the existing forms of IBP in the solution and the electric charge of TiO₂ surface were controlled by pH. The photocatalytic degradation rate of IBP was significantly affected by H₂O₂ dosage, and the suitable, amount of H₂O₂ was about 2.5 mg/L. It was also indicated that TOC was removed effectively. According to the LC-MS data, hydroxylation addition to the parent pharmaceutical was proposed as the fundamental degradation pathway.