Abstract: As a kind of introductive alien plant, Coreopsis grandiflora has become an invasive species in Shandong and other regions of China due to its strong reproductive capacity and ability to adapt, and has threatened the local ecosystem. Based on global altitude variable and 19 climate variables, the potential distribution of C. grandiflora in China was predicted by maximum entropy(Maxent)models and geographic information system(ArcGis). Results showed that the suitable distribution of C. grandiflora in China ranged 98°-125°E, 21.5°-43°N, the warm temperate and subtropical zone. C. grandiflora mainly concentrated in eastern China and central China including Jiangsu, Anhui, Shanghai and Shandong. The southern China and southwest of China were middle or low suitable areas. The other parts of China were unfavorable for the growth of C. grandiflora. The ROC carve indicated that the AUC Value based on the datas of treating and testing were 0.960,0.965,respectively, showed high predictive accuracy. With the highest contribution percentages, annual mean temperature, annual mean precipitation, mean temperature of coldest quarter were the three most important environmental factors influencing the distribution of the species. Based on the results of Maxent model, its biological characteristics and invasive status in China, it is necessary to take some effective measure to restrict the extending of the species in central and east China.