The cable structure antiseptic systems in China are all under destructive situation at present. The destructive causes of the cable antiseptic system were analyzed for cable structures. The results showed that the lifespan of cable could be lengthen by choosing two-humped PE sheath as well as stuffing something inside the cable that had such effects as steam isolation anti-corrosion lubrication and friction-resistence. The cable antiseptic system of the Nanjing No.3 Yangtze River Bridge was developed and put to use. The system includes PE sheath, the filling materials in the cable, the antiseptic system on the assembled cable.