Characterization and preparation of dehydroabietylamine 4hydroxysalicylidene Schiff base βcyclodextrin inclusion complex

doi:10.3969/j.jssn.1000-2006.2011.01.014

JOURNAL OF NANJING FORESTRY UNIVERSITY ›› 2011, Vol. 35 ›› Issue (01): 62-66.doi: 10.3969/j.jssn.1000-2006.2011.01.014

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Characterization and preparation of dehydroabietylamine 4hydroxysalicylidene Schiff base βcyclodextrin inclusion complex

CHEN Yong, LIN Zhongxiang, ZHANG Danhong

1. College of Science, Nanjing Forestry University, Nanjing 210037, China; 2. College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

Online:2011-01-14 Published:2011-01-14

Abstract

Abstract: Dehydroabietylamine 4hydroxysalicylidene Schiff base complexes enwrapped with βcyclodextrin were prepared by the method of saturation solution, and were identified with IR, DSC and UV. The antitumor activities of the dehydroabietylamine 4hydroxysalicylidene Schiff base and the inclusion complexes were studied. The main results were as follows: The inclusion complex was formed at the 1∶1 molar ratio of dehydroabietylamine 4hydroxysalicylidene Schiff base and βcyclodextrin; the solubility of dehydroabietylamine 4hydroxy salicylidene Schiff base in mixed solvent (V(DMSO)∶V(H2O)=1∶1) was increased by 34 folds after complexing with βcyclodextrin; the inhibitory ratios of the dehydroabietylamine 4hydroxysalicylidene Schiff base and its inclusion complex on ovarian cancer cell line (Hey1B) were 5034% and 4165 %, respectively, at the concentration of 10 μg/mL.

CLC Number:

TQ351

CHEN Yong, LIN Zhongxiang, ZHANG Danhong. Characterization and preparation of dehydroabietylamine 4hydroxysalicylidene Schiff base βcyclodextrin inclusion complex[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY, 2011, 35(01): 62-66.

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Characterization and preparation of dehydroabietylamine 4hydroxysalicylidene Schiff base βcyclodextrin inclusion complex

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