Advance in transcriptional factors regulating flavonoid biosynthesis

doi:10.3969/j.jssn.1000-2006.2011.05.029

JOURNAL OF NANJING FORESTRY UNIVERSITY ›› 2011, Vol. 35 ›› Issue (05): 129-134.doi: 10.3969/j.jssn.1000-2006.2011.05.029

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Advance in transcriptional factors regulating flavonoid biosynthesis

LI Zongyan^1,2，LI Mingyang¹*

1.College of Horticulture and Landscape, Southwest University, Chongqing 400716, China; 2.Faculty of Landscaping  and Architecture, Southwest Forestry University, Kunming 650224, China

Online:2011-09-30 Published:2011-09-30

Abstract

Abstract: Variation of plant color was determined by many inner factors, including pigments and their contents, pigments distribution,and morphology of flower epidemical cell. We collected many documents from different perspectives to illustrate the advance in the transcriptional factors(TFS) regulated on flavonoid biosynthesis. Based on related study, there were three types of transcriptional factors involving in regulation process. Myb，bHLH and WD40 TFs in regulating the processes of plant anthocyanidin synthesis were analyzed for their chemical structures and other relevant functions. The homologous genes cloned so far were listed in this review. Moreover, their coexpression traits involved in same or different types of TFS were summarized for the main genes studied in model plants. Many TFS were found to regulate both anthocyanin biosynthesis and trichome development and differentiation, such as CPC and TTG1. Evolutional traits of TFS were summarized. Their applications for plant color breeding and selection were also discussed.

CLC Number:

Q781

LI Zongyan，LI Mingyang*. Advance in transcriptional factors regulating flavonoid biosynthesis[J]. JOURNAL OF NANJING FORESTRY UNIVERSITY, 2011, 35(05): 129-134.

References

[1]Brenda W S. Flavonoid biosynthesis:A colorful model for genetics, biochemistry, cell biology, and biotechnology[J]. Plant Physiol, 2001, 126（2）: 485-493.
[2]Doebley J, Lukens L. Transcriptional regulators and the evolution of plant form[J]. Plant Cell, 1998, 10（7）: 1075-1082.
[3]Stracke R, Werber M, Weisshaar B. The R2R3MYB gene family in Arabidopsis thaliana[J]. Plant Biology, 2001, 4（15）: 447-456.
[4]Ogata K, Morikawa S, Nakamura H, et al. Solution structure of a specific DNA complex of the Myb DNAbinding domain with cooperation helices[J]. Cell, 1994,79(4):639-648.
[5]Kranz H, Scholz K, Weisshaar B. cMYB oncogenelike genes encoding three MYB repeats occur in all major plant lineages[J]. Plant Journal, 2000, 21（2）: 231-235.
[6]PazAres J, Ghosal D, Saedler H. Molecular analysis of the C1I allele from Zea mays: a dominant mutant of the regulatory C1 locus[J]. EMBO Journal, 1990, 9（2）: 315-321.
[7]Hernandez J M，Heine G F, Irani N G, et al. Different mechanisms participate in the Rdependent activity of the R2R3 MYB transcription factor C1[J]. J Biol Chem, 2004, 279（46）: 48205-48213.
[8]Laurent D, Jochen B, Amanda R, et al. The transcription factor VvMYB5b contributes to the regulation of anthocyanin and proanthocyanidin biosynthesis in developing grape berries[J]. Plant Physiology, 2008, 147（4）:2041-2053.
[9]Dubos C, Le Gourrierec J, Baudry A,et al. MYBL2 is a new regulator of flavonoid biosynthesis in Arabidopsis thaliana[J]. Plant Journal, 2008, 55(6): 940-953
[10]Zhu H F, Fitzsimmons K, Khandelwal A,et al. CPC, a singlerepeat R3 MYB, is a negative regulator of anthocyanin Biosynthesis in Arabidopsis[J]. Molecular Plant, 2009, 2(4): 790-802.
[11]Nakatsuka T, Haruta K S, Pitaksutheepong, et al. Identification and characterization of R2R3MYB and bHLH transcription factors regulating anthocyanin biosynthesis in gentian flowers[J]. Plant and Cell Physiology, 2008, 49 (12) : 1818-1829.
[12]Quattrocchio F, Wing J, Vander W K, et al. Molecular analysis of the anthocyanin2 gene of Petunia and its role in the evolution of flower color[J]. Plant Cell, 1999, 11(8):1433-1444.
[13]Borevitz J O, Xia Y, Blount J, et al. Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis[J]. Plant Cell, 2000, 12(12):2383-2394.
[14]Schwinn K, Venail J, Shang Y J, et al. A small family of MYBregulatory genes controls floral pigmentation intensity and patterning in the genus Antirrhinum[J]. Plant Cell, 2006, 18(4):831-851
[15]Atchley W R, Fitch W M. A natural classification of the basic helixloophelix class of transcription factors[J]. Proc Natl Acad Sci, 1997, 94 (10): 5172-5176.
[16]Perrot G H,Cone K C. Nucleotide sequence of the maize RS gene[J]. Nucleic Acids Res, 1989, 17(19):8003.
[17]Goodrich J, Carpenter R, Coen E S. A common gene regulates pigmentation pattern in diverse plant species[J]. Cell,1992, 68(5):955-964
[18]Spelt C, Quattrocchio F, Mol J N, et al. anthocyanin1 of petunia encodes a basic helixloophelix protein that directly activates transcription of structural anthocyanin genes[J]. Plant Cell, 2000, 12(9): 1619-1631
[19]Neer E J, Schmidt C J, Nambudripad R,et al. The ancient regulatoryprotein family of WDrepeat proteins[J]. Nature,1994, 371(6495):297-300.
[20]de Vetten N, Quattrocchio F, Mol J, et al. The an11 locus controlling flower pigmentation in petunia encodes a novel WDrepeat protein conserved in yeast, plants, and animals[J]. Genes Dev, 1997, 11(11): 1422-1434.
[21]Walker A R, Davison P A, BolognesiWinfield A C, et al. The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis,encodes a WD40 repeat protein[J]. Plant Cell, 1999, 11(7):1337-1350.
[22]Morita Y, Saitoh M, Hoshino A, et al. Isolation of cDNAs for R2R3MYB, bHLH and WDR transcriptional regulators and identification of c and ca mutations conferring white flowers in the Japanese morning glory[J]. Plant and Cell Physiology, 2006, 47(4): 457-470.
[23]Pang Y Z, Wenger J P, Saathoff K,et al. A WD40 repeat protein from Medicago truncatula is necessary for tissuespecific anthocyanin and proanthocyanidin biosynthesis but not for trichome development[J]. Plant Physiology, 2009, 151(3): 1114-1129.
[24]Johnson C S, Kolevski B, Smyth D R. TRANSPARENT TESTA GLABRA2, a trichome and seed coat development gene of Arabidopsis, encodes a WRKY transcription factor[J]. Plant Cell, 2002, 14(6):1359-1375.
[25]Sablowski R W, Moyano E, CulianezMacia F A, et al. A flowerspecific Myb protein activates transcription of phenylpropanoid biosynthetic genes[J]. EMBOJ, 1994, 13(1):128-137.
[26]Moyano E, MartinezGarcia J F, Martin C. Apparent redundancy in myb gene function provides gearing for the control of flavonoid biosynthesis in Antirrhinum flowers[J]. Plant Cell, 1996, 8(9):1519-1532.
[27]Meissner R C, Jin H L, Cominelli E, et al. Function search in a large transcription factor gene family in Arabidopsis: assessing the potential of reverse genetics to identify insertional mutations in R2R3MYB genes[J]. Plant Cell, 1999, 11(10):1827-1840.
[28]Ramsay N A, Walker A R, Mooney M, et al. Two basichelixloophelix genes(MYC146 and GL3)from Arabidopsis can activ〖LM〗Nesi N, Debeaujon I, Jond C, et al. The TT8 gene encodes a basic helixloophelix domain protein required for expression of DFR and BAN genes in Arabidopsis siliques[J]. Plant Cell, 2000, 12(10):1863-1878.
[30]Jin H, Martin C. Multifunctionality and diversity within the plant MYBgene family[J]. Plant Mol Biol, 1999, 41(5):577-585.
[31]Stracke R, Ishihara H, Huep G, et al. Differential regulation of closely related R2R3MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling[J]. Plant J, 2007, 50(4): 660-677.
[32]Mehrtens F, Kranz H, Bednarek P, et al. The Arabidopsis transcription factor MYB12 is a flavonolspecific regulator of phenylpropanoid biosynthesis[J]. Plant Physiology, 2005, 138(2): 1083-1096.
[33]Yuan Y X, Chiu L W, Li L. Transcriptional regulation of anthocyanin biosynthesis in red cabbage[J]. Planta, 2009,230(6): 1141-1153.
[34]Wei Y L, Li J N, Lu J, et al. Molecular cloning of Brassica napus TRANSPARENT TESTA 2 gene family encoding potential MYB regulatory proteins of proanthocyanidin biosynthesis[J]. Mol Biol Rep, 2007, 34(2):105-120.
[35]Elomaa P, Uimari A, Mehto M, et al. Activation of anthocyanin biosynthesis in Gerbera hybrida (Asteraceae) suggests conserved proteinprotein and proteinpromoter interactions between the anciently diverged monocots and eudicots[J]. Plant Physiology, 2003, 133(4): 1831-1842.
[36]Wu X M, Lim S H, Yang W C. Characterization, expression and phylogenetic study of R2R3MYB genes in orchid[J]. Plant Mol Biol, 2003, 51(6):959-972.
[37]Nakatsuka A, Yamagishi M, Nakano M, et al. Lightinduced expression of basic helixloophelix genes involved in anthocyanin biosynthesis in flowers and leaves of Asiatic hybrid lily[J]. Scientia Horticulturae，2009,121(1): 84-91.
[38]Chiou ChungYi, Yeh KaiWun. Differential expression of MYB gene (OgMYB1) determines color patterning in floral tissue of Oncidium Gower Ramsey[J]. Plant Molecular Biology, 2008, 66(4):379-388.
[39]Ban Y, Honda C, Hatsuyama Y, et al. Isolation and functional analysis of a MYB transcription factor gene that is a key regulator for the development of red coloration in apple skin[J]. Plant Cell Physiol, 2007, 48(7):958-970.
[40]Takos A M, Jaffé F W, Jacob S R, et al. Lightinduced expression of a MYB ge

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Advance in transcriptional factors regulating flavonoid biosynthesis

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