JOURNAL OF NANJING FORESTRY UNIVERSITY ›› 2013, Vol. 37 ›› Issue (02): 151-155.doi: 10.3969/j.issn.1000-2006.2013.02.027

Previous Articles     Next Articles

Synthesis and bacteriostatic activity of benzimidazole compounds

HUANG Tao,CHENG Kanghua*,GU Xiaoli   

  1. College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
  • Online:2013-04-18 Published:2013-04-18

Abstract: To find new organic wood preservative with broad-spectrum and hyperactivity, seven 5-substituted benzimidazole compounds were synthesized from 4-substituted ο-phenylenediamine through multi-step reactions including acylation, cyclization and so on. Their chemical structures were confirmed by melting points, MS, 1H NMR and elemental analysis. The target compounds were screened for antimicrobial activity by agar-well diffusion method against white-rot fungi(Coriolus versicolor), brown-rot fungi(Gloeophyllum trabeum)and moulds(Aspergillus niger and Trichoderma viride). The preliminary fungicidal tests showed that seven compounds had no fungicidal activities, but some of them had anti-mould activities. Compound 4a at concentration of 1.0% showed strong anti-mould activity which was significantly higher than that of pentachlorophenate, and compounds 4b was equal to contrast.

CLC Number: